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Change from basal insulin to a basal-bolus insulin regimen The basal-plus regimen is usually started first, or prandial insulin is added in all three main meals.25,26 Specific clinical situationsInsulin therapy in patients with T2DM and chronic kidney disease The risk of severe hypoglycemia is two times higher in chronic kidney disease.2731 Less intensive blood glucose monitoring is usually recommended, unless drugs with no risk of hypoglycemia are used.22 The insulin therapy regimen should be adapted to control goals